Serum, plasma, cell culture medium, salvia, breast milk and urine.

Haemolytic samples appear to show falsely high Resistin levels. Whole blood should be chilled as soon as possible following collection. Serum and plasma samples are stable for maximal 2 days at room temperature. Long-term storage at -20°C, stable for maximal 2 years. Maximum 3 freeze/thaw cycles.

Women:   7.0 ng/ml +/- 2.5 SD (referred to BMI ~ 25 kg/m²)
Men:          6.0 ng/ml +/- 2.5 SD (referred to BMI ~ 25 kg/m²)

Human

Resistin (FIZZ3) is a hormone influencing fat metabolism and inflammation processes. In humans, it is expressed in bone marrow and transported by macrophages into adipose tissue. Resistin stimulates pre-adipocyte proliferation and lipolysis of mature adipocytes probably by influencing MAPK signaling. With regard to the importance of Resistin in disorders of energy metabolism, a significant reduction could be shown in patients with anorexia nervosa. It has been demonstrated that Resistin enhances the expression of specific cell markers such as VACM-1 and ICAM-1 and thus may influence endothelial inflammatory processes, and thereby arteriosclerosis. Moreover, due to its association with Endothelin-1, Resistin also plays a role in cardiovascular diseases.

Resistin is relevant to medical conditions such as:
• Obesity
• Insulin resistance, diabetes
• Arteriosclerosis
• Inflammation
• Lipolysis